Sofosbuvir
J - Antiinfectives For Systemic Use -> J05 - Antivirals For Systemic Use -> J05A - Direct Acting Antivirals -> J05AX - Other Antivirals -> J05AX15 - Sofosbuvir
Administration category:
Free
Medicine group:
antiviral
Brand name:
Sovaldi
Standard dosages
| Weight | ROA | Load | Dosage |
|---|---|---|---|
|
ROA: po |
Load: - |
Dosage: 400mg 1 dd |
Kidney function
| ROA | GFR | Dosage | Interval | Comments |
|---|---|---|---|---|
| ROA: po | ||||
|
GFR: 30 - 50 |
Dosage: geen aanpassing |
|||
|
GFR: <30 |
Dosage: gebruik vermijden |
|||
Renal elimination:
80%
Dosage:
dependent on kidney function
Renal function-replacement therapy
CAPD: gebruik vermijden
Hemo dialysis: gebruik vermijden
Interactions
| Interaction with (ATC): | Interaction with: | Expected effect: |
|---|---|---|
|
Interaction with (ATC): C01BD01 - Amiodarone |
Interaction with: |
Expected effect: indien gecombineerd met daclatasvir: ernstige bradycardie en AV-blokkade |
|
Interaction with (ATC): |
Interaction with: niet gelijktijdig toedienen met krachtige inductoren van Pgp of BCRP zoals rifampicine, rifabutine, carbamazepine, oxcarbazepine, fenytoïne, fenobarbital, en sint-janskruid. |
Expected effect: verlaging bloedspiegel |
Pregnancy
Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:
- http://www.lareb.nl//Teratologie/Naslagwerk-GZB/GZB---Zwangerschap#TOC_Middelen_bij6
- http://www.lareb.nl//Teratologie/Naslagwerk-GZB/GZB---Borstvoeding#TOC_Middelen_bij16
For individual advice, consult an expert on site.
Metadata
Swab vid: M-287563.2
Updated: 07/11/2022 - 11:16
Status: Published